Flea and Tick Pills for Dogs


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Flea and tick pills are oral medications formulated specifically to prevent and treat infestations in dogs. Unlike topical treatments or collars, these pills are ingested and work from the inside out.

No dog is immune to the risk of fleas and ticks, especially when they play outdoors. Fleas can lead to allergies, dermatitis, and even tapeworms, while ticks can transmit diseases such as Lyme disease or Rocky Mountain spotted fever. A single bite from these pests can lead to a multitude of problems, making prevention paramount.

Flea And Tick Pills For Dogs

Oral treatments come with several advantages. They often work faster than other treatments, don’t wash off during baths or rain, and there’s no risk of them rubbing off on furniture or human skin. Moreover, they eliminate the need for messy applications and ensure consistent protection as long as the medication remains effective.

As you delve into this article, we’ll provide a comprehensive review of the best flea and tick pills available for dogs, aiding you in making an informed decision for the safety and comfort of your furry companion.

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Dog Flea and Tick Pills Reviews

Knowing the best option can be challenging with so many flea and tick pill brands for dogs on the market. But not to worry, we have researched for you. 

After evaluating dozens of flea and tick pills for your furry companion, we have shortlisted the best dog flea and tick pill options here. We have analyzed based on features, key ingredients, customer reviews, and feedback. 

In this article, we will review the following flea and tick pills for dogs.

Best Flea and Tick Pills for Dogs

Capstar Flea Treatment for Dogs

For Small Dogs, 2 to 25 lbs

Capstar Flea Pills for Large Dogs

For Large Dogs, 26 to 125 lbs

CAPSTAR Flea Pills, designed for both small and large dogs, offer a robust defense against flea infestations. These pills are backed by strong research and practical results. With the inclusion of six doses per package, it provides ample coverage for your pet. 

One of its standout features is the rapid onset of action—upon administration, the oral tablet begins its flea-fighting action within 30 minutes. It’s not just about speed; it’s about efficacy. As you watch, you’ll notice fleas falling off, signifying the potency of CAPSTAR’s formula.

The active ingredient, Nitenpyram, powers the pills. This chemical compound is renowned for its swift action against adult fleas, exterminating them within a mere 4 hours. 

For those concerned about younger pups or expectant mothers, CAPSTAR is deemed safe for puppies as young as four weeks, and those weighing a minimum of 2 pounds. It also offers the convenience of being safe for pregnant or nursing pets.

One of the remarkable aspects of CAPSTAR is its re-dosing flexibility. While a single dose is typically sufficient to eliminate current infestations, in case your dog faces a re-infestation, you have the liberty to administer another dose even as frequently as once a day. 

This feature demonstrates the product’s adaptability to varying flea challenges. Moreover, the tablet’s design eliminates the mess and odor associated with many other flea treatments. 

And if you don’t exhaust the doses in one go, the remaining tablets retain their potency when stored correctly.

While CAPSTAR Flea Pills are available without a vet’s prescription, it’s always advised to refer to the package insert for comprehensive information before administration.

Key Ingredient: Nitenpyram

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Advantus Flea Pills Oral Treatment For Small Dogs

For Small Dogs, 4 to 22 lbs

Advantus Flea Pills for Large Dogs

For Large Dogs, 23 to 110 lbs

Advantus presents a commendable solution in the fight against fleas with its Oral Treatment for Dogs, particularly designed for the lighter weight range. 

The treatment’s key ingredient, imidacloprid, an insect neurotoxin, stands out for its exceptional speed and efficacy. 

Within an hour of administration, it starts its relentless attack, paralyzing and eliminating the adult fleas. This speed is a testament to the potency and reliability of the treatment.

Designed as a soft chew, the administration process is a breeze. Instead of wrestling with your pet or dealing with the oft-dreaded process of applying topical treatments, this chewable can be effortlessly handed to the dog, doubling as a treat. 

This means no spills, no residues, and more importantly, no distress for both the pet and the owner.

A notable benefit of Advantus is its suitability for younger canines. Dogs and puppies as young as 10 weeks and weighing a minimum of 4 pounds can safely receive this treatment. 

Additionally, in cases of persistent infestations, the flexibility to administer treatments daily ensures that your pet remains safeguarded.

Moreover, the absence of a mandatory prescription for this treatment offers convenience to pet owners. It ensures that they can have a ready supply to counter infestations without delay. 

The treatment, while being potent against fleas, does away with the complications often associated with messy topical treatments, making it a favored choice for many.

Key Ingredients: Imidacloprid.

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Nexgard Flea Tick Treatment Oral Chewables Small Dog

For Small Dogs
4 to 10 lbs

Nexgard Flea Tick Treatment Oral Chewables Medium Dog

For Medium Dogs
10.1 to 24 lbs

Nexgard Flea Tick Treatment Oral Chewables Large Dog

For Large Dogs
24.1 to 60 lbs

Nexgard Flea Tick Treatment Oral Chewables Extra Large Dog

For X-Large Dogs
60.1 to 120 lbs

Key Ingredients: 136 mg Afoxolaner.

In the ever-evolving realm of flea and tick treatments, Nexgard stands out, particularly for extra-large canine companions. This monthly preventive treatment, vet-recommended and FDA-approved, delivers on its promise with efficacy and swiftness. 

Its beef-flavored chews, crafted to be both palatable and easy to administer, ensure that the treatment process is as delightful for the pet as it is straightforward for the owner.

Nexgard’s potency lies in its proactive approach. Not only does it target adult fleas, but it also halts their life cycle by preventing them from laying eggs. This twofold strategy ensures reduced chances of reinfestations. 

Beyond fleas, the treatment addresses various tick species like the American dog ticks. This broad spectrum makes it a formidable defense against tick-borne diseases, including the severe Lyme disease.

A highlight of this treatment is its rapid onset. Within a mere 8 hours post-administration, pet owners can start observing its effects. Yet, its duration isn’t compromised; a single chew offers protection lasting an entire month.

Nexgard’s chewables, though potent, are designed with a dog’s well-being in mind. Suitable for puppies as young as 8 weeks and weighing at least 4 pounds, its versatility is commendable. 

As an assurance of authenticity and quality, these chewables are sourced directly from either the manufacturer or their approved distributor.

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Coloradodog EcoFlea Flea and Tick Control Dog Treats

EcoFlea has designed an oral flea and tick treatment for dogs that primarily relies on natural and organic ingredients. One of its primary components is garlic, historically recognized for its repellent properties against pests. 

Alongside garlic, brewer’s yeast has been integrated, offering another layer of protection against these pesky intruders.

The chews are formulated to be both effective and palatable, with a bacon flavor that most dogs typically favor. With 120 chews in a bottle, it provides a sufficient supply to address infestations and prevent them over time. 

A significant advantage is its non-reliance on chemicals or fillers. There’s an evident absence of ingredients like corn, soy, added sugars, or dairy, ensuring that the chews are as pure as they are potent.

Manufactured in the USA, these chews are produced in an FDA-registered facility, which inherently signals a commitment to upholding quality and safety standards. The emphasis here is clear: a natural, effective, and safe way to deal with and prevent flea and tick issues in dogs.

Key Ingredients:  Garlic, Brewer’s yeast, Soy

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Flea Away Flea Pills for dogs

Flea Away, with its comprehensive approach to repelling pests, offers an all-natural solution that serves as a barrier against fleas, ticks, and mosquitoes. The product is not just about repelling pests; it’s designed keeping in mind the overall well-being of your pet. 

With a foundation based on a vitamin complex, it adheres to FDA human standards, ensuring the safety of your pet is never compromised.

One of the remarkable aspects of Flea Away is its proactive approach. Instead of just killing the pests, it ensures they are repelled even before they have the chance to bite. This is crucial, especially for pets that are allergic to flea bites. 

The liver-flavored chewable tablets make administration effortless, and with 100 tablets per bottle, it offers an ample supply based on your pet’s weight.

A noteworthy feature is its compatibility with nursing mothers and their litter, emphasizing its non-toxic nature. Beyond just repelling pests, Flea Away provides an added advantage by promoting healthier skin, reducing shedding, enhancing the shine of the coat, and improving joint health.

Key Ingredients: Proprietary blend of (Brewer’s Yeast, Calcium Carbonate, Cyanocobalamin, Folic Acid, Niacin, Pyridoxine HCl, Thiamine HCl, dl-alpha-tocopheryl acetate), Beef Liver, Gelatin, Gelatin Hydrolysate Beef, Magnesium Stearate, Microcrystalline Cellulose, Silica, Stearic Acid.

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CapAction introduces a straightforward approach to tackling flea infestations in pets. With its set of 6 tablets, it promises not only an immediate response to existing fleas but also provides a safety net for potential re-infestations. 

The effectiveness of this product begins within a startling 30 minutes of administration, emphasizing its claim of fast action.

What makes CapAction notable is its emphasis on safety. Designed specifically for small dogs weighing between 2-25 lbs and aged 4 weeks or older, it caters to a segment of pet owners who might find limited options in the market. 

Furthermore, the provision to administer additional doses, in case of re-infestations, as frequently as once per day, provides peace of mind to pet owners. This flexibility doesn’t compromise safety, with the product even being recommended for pregnant or breeding dogs.

Moving beyond the application, CapAction eliminates the mess and potential inaccuracies associated with topical treatments. Its oral administration ensures full intake and acts directly to eradicate adult fleas, which could otherwise lead to allergy dermatitis in some pets.

Key Ingredient: Nitenpyram

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CapAction Oral Flea Treatment Large Dogs

CapAction Oral Flea Treatment demonstrates a commendable approach to tackling flea challenges for larger pets. Packaged with 6 tablets, this medication swiftly addresses adult flea infestations, proving its efficiency within a mere 30 minutes post-administration.

Its versatility is evident in its compatibility not only with large dogs but also with cats and kittens weighing 25 lbs and over. A crucial factor for many pet owners is safety, and CapAction doesn’t disappoint. 

The liberty to administer additional doses daily, in case of a resurgence of fleas, showcases its adaptability without compromising the pet’s health. Remarkably, its safety extends even to pregnant or breeding animals.

Besides its efficacy, CapAction offers ease of application. The oral treatment format is not only mess-free but also circumvents the potential inconsistencies of topical treatments. 

The product zeroes in on adult fleas, aiming to prevent allergic reactions in pets due to flea bites.

Key Ingredient: Nitenpyram

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What Are Fleas And Ticks?


Fleas are tiny, wingless insects that belong to the order Siphonaptera. They are external parasites, meaning they live outside of their host’s body and primarily feed on the blood of mammals and birds.

Physical Characteristics: Adult fleas are usually 1 to 3 mm long, with a dark, reddish-brown color. They possess specialized mouthparts for piercing skin and sucking blood.

Lifecycle: The life cycle of a flea consists of four stages: egg, larva, pupa, and adult. While adult fleas feed on blood, larvae feed on organic debris found in their environment.

Host Range: While there are many species of fleas, some of the most common ones that affect dogs include the cat flea (Ctenocephalides felis) and dog flea (Ctenocephalides canis). Despite their names, both species can infest a range of hosts.

Impact on Host: Fleas can cause itching, allergic reactions, and secondary skin infections in their hosts. They can also transmit tapeworms and cause anemia in severe infestations.


Ticks are arachnids, putting them in the same class as spiders and mites. Like fleas, they are external parasites that feed on the blood of mammals, birds, and sometimes reptiles and amphibians.

Physical Characteristics: Ticks vary in size, from as small as a pinhead to as large as a pencil eraser. They can expand significantly when engorged with blood. They have a flattened oval or pear-shaped body and possess four pairs of legs in their adult stage.

Lifecycle: The tick life cycle includes four stages; egg, larva (6-legged), nymph, and adult (8-legged). Different species have different life cycle patterns, but all require a blood meal to move on to the next stage.

Host Range: There are various species of ticks. Some, like the Deer tick (Ixodes scapularis) or the Brown dog tick (Rhipicephalus sanguineus), are of particular concern for dogs and their owners due to their ability to transmit diseases.

Impact on Host: Ticks are notorious for transmitting diseases, including Lyme disease, Rocky Mountain spotted fever, and Ehrlichiosis. Additionally, a heavy infestation can cause anemia, especially in young animals.

In a nutshell, both fleas and ticks are external parasites that feed on the blood of their hosts. While they share some similarities in behavior and impact, they belong to entirely different biological classifications and bring their unique set of challenges for pets and pet owners. 

Proper prevention and treatment are crucial to keep our furry friends safe from these pests.

What Are The Types of Flea and Tick Treatments for Dogs?

Flea and tick treatments for dogs have evolved over the years, with various options now available to suit different needs and preferences. Here’s an overview of the primary types of flea and tick treatments:

Topical Spot-On Treatments

These are liquid treatments that are applied directly to the dog’s skin, typically between the shoulder blades or along the back.

How They Work: Once applied, the treatment spreads over the dog’s body, providing full-body protection. It targets fleas, ticks, and sometimes other pests, either killing on contact or when the pest bites.

Examples: Products like Frontline Plus, Advantage II, and Revolution.

Oral Medications (Pills or Chewables)

These are ingested by the dog and work systemically.

How They Work: When fleas or ticks bite and consume the dog’s blood, they ingest the active ingredient, which either kills or sterilizes them.

Examples: Products like NexGard, Bravecto, and Comfortis.

Flea and Tick Collars

These are collars infused with chemicals that repel and/or kill fleas and ticks.

How They Work: The collar releases the active ingredient over time, which is distributed over the dog’s body via the natural oils on their skin.

Examples: Seresto collar, Preventic collar.


These are specially formulated shampoos that contain ingredients to kill fleas and ticks.

How They Work: Washing a dog with flea and tick shampoo can provide immediate relief, killing pests on contact. However, the protection is often short-lived, usually lasting less than a week.


These are liquid solutions that can be sprayed directly onto a dog’s coat.

How They Work: They offer immediate protection, killing fleas and ticks on contact. Some sprays also provide repellent properties.


These are finely ground powders that are sprinkled over the dog’s body.

How They Work: The active ingredients in the powder kill fleas and ticks on contact. However, they might not offer as long-lasting protection as some other treatments.


These are concentrated liquid treatments where the dog is immersed, or it’s applied using a sponge.

How They Work: They contain strong chemicals that kill fleas, ticks, and other pests on contact.

Natural or Herbal Remedies

These are treatments formulated using natural ingredients rather than synthetic chemicals.

How They Work: Many natural treatments repel fleas and ticks using essential oils or other botanicals, though their efficacy can vary.

Examples: Products containing cedar oil, lemon eucalyptus oil, or neem oil.

Environmental Treatments

These are treatments designed for the dog’s environment, such as their bedding, home, or yard.

How They Work: They help in controlling the flea and tick population in the surroundings, preventing new infestations. This can include sprays, foggers, and powders for indoor use, and yard sprays or granules for outdoor use.

Benefits Of Flea and Tick Pill for Dogs

Flea and tick pills, which are a form of oral medication for dogs, have gained popularity over the years due to several inherent benefits. Here are some of the primary advantages of using flea and tick pills for dogs:


Many oral treatments work quickly, often killing fleas and ticks within hours of administration. This rapid action can provide immediate relief to infested pets.

Long-Lasting Protection

Some oral medications offer extended protection, ranging from a month up to several months, depending on the product. This prolonged efficacy means fewer doses, which can be convenient for pet owners.

No Mess

Unlike topical treatments, there’s no liquid to apply, which means no residue on the dog’s fur or potential stains on furniture or flooring.

Won't Wash Off

Because the medication is ingested, there’s no risk of it washing off during baths, swimming, or rainy weather. This ensures consistent protection.

Precise Dosage

Oral medications eliminate the guesswork involved in applying a liquid accurately on the skin. This ensures that the dog receives the exact dose required.

Less Risk of Human Exposure

There’s no external residue with oral treatments, reducing the chances of humans, especially children, coming into contact with the active ingredients.

Broad Spectrum of Action

Some oral medications not only target fleas and ticks but also other pests and internal parasites, providing comprehensive protection.

Reduced Skin Reactions

Some dogs might be sensitive to topical treatments, leading to skin irritations or allergic reactions. Oral treatments can be an excellent alternative for such pets.

Avoidance of Resistance

Regularly switching between different types of treatments (like topical to oral) can help prevent fleas and ticks from developing resistance to a particular kind of medication.

Ease of Administration

Many flea and tick pills are flavored or can be disguised in food, making it easier to administer to dogs that might resist other forms of treatment.

Consistent Efficacy

The effectiveness of some topical treatments might diminish over time, especially toward the end of the treatment cycle. In contrast, oral medications tend to provide a consistent level of protection throughout their efficacy.

Decreased Risk of Transmission

By rapidly killing fleas and ticks, oral treatments reduce the risk of diseases these pests can transmit, such as Lyme disease, Rocky Mountain spotted fever, and flea allergy dermatitis.

Improved Pet Comfort

Since oral medications act from within, they can offer relief without the pet feeling anything on their skin, which can be beneficial for pets sensitive to external applications.

Less Chance of Missed Spots

Topical treatments require proper application to ensure full coverage, and there’s always a chance of missing a spot. Oral medications, being systemic, eliminate this concern.

Reduced Environmental Contamination

With no external residue, there’s no risk of chemicals from the treatment contaminating water sources or the environment, especially when the dog swims or bathes.

Compatibility with Other Treatments

Some oral flea and tick pills can be safely administered alongside other medications or treatments, allowing comprehensive health care without interference.

Peace of Mind

Knowing that your dog is protected from the inside out gives many pet owners peace of mind, especially in areas where fleas and ticks are prevalent.


While the upfront cost of some oral treatments might be higher than other options, their extended protection and comprehensive coverage can make them more cost-effective in the long run.

Reduced Infestation Cycles

Some oral medications not only kill adult fleas but also interrupt the flea life cycle, preventing future infestations.

Safe Storage

Since there’s no risk of spillage or leakage, flea and tick pills can be safely stored without concerns about contaminating other items.

Factors To Consider When Buying Flea and Tick Pills

Selecting the right flea and tick pill for your dog requires careful consideration to ensure safety, effectiveness, and comfort for your pet. Here are some factors to keep in mind when making a decision:

Dog's Age

Some oral medications may not be suitable for puppies or older dogs. Always check the age recommendation on the product.

Weight and Size

Dosages are often determined by the dog’s weight. Ensure you choose a product designed for your dog’s weight range to prevent under-dosing or overdosing.

Health and Medical History

Some dogs may have health conditions or allergies that might make certain treatments unsuitable. Discuss any health concerns with your veterinarian.

Species Coverage

Not all treatments cover every species of flea or tick. Depending on the region and specific pests you’re targeting, ensure the medication protects against the relevant species.

Duration of Effectiveness

Check how long the medication remains effective after each dose. Some pills offer a month’s protection, while others might work for several months.

Additional Parasite Protection

Some oral treatments also protect against other parasites, such as heartworms, roundworms, or mites. If you want broad-spectrum protection, consider these multi-purpose products.

Ease of Administration

Some dogs can be fussy about taking pills. Consider whether the pill can be crushed or hidden in food or if it comes in a flavored chewable form.

Side Effects

Research potential side effects of the product. Common side effects might include vomiting, diarrhea, loss of appetite, or lethargy. Monitor your dog closely after administering a new treatment.


While cost shouldn’t be the only factor, it’s essential to find a treatment that fits within your budget, especially if long-term use is needed.

Brand Reputation

Opt for reputable brands with proven efficacy and safety records. Customer reviews and veterinarian recommendations can be helpful.

Approval and Certification

Ensure the product is approved by relevant regulatory bodies, such as the Food and Drug Administration (FDA) or the Environmental Protection Agency (EPA) in the U.S.

Lifestyle and Environment

If your dog frequently swims or is exposed to heavy rain, while this might not wash off oral treatments, it could indicate a higher exposure to pests in certain environments.

Frequency of Outdoor Activities

Dogs that spend more time outdoors, especially in wooded or grassy areas, may have a higher risk of flea and tick infestations.

Resistant Strains

In some areas, fleas and ticks may develop resistance to certain treatments. Stay informed about local resistance patterns and adjust your choice accordingly.

Interactions with Other Medications

If your dog is on other medications, consult with your veterinarian to ensure there are no harmful interactions.

Guarantee or Warranty

Some companies may offer satisfaction guarantees or warranties, providing a refund or replacement if the product doesn’t work as advertised.

Frequently Asked Questions (FAQs)

Use preventive tick treatments like oral pills, topical solutions, or tick collars. Regularly check your dog’s coat after outdoor activities, maintain a clean environment, and keep the grass short in your yard.

Many treatments are monthly, but it depends on the product. Some last longer, and others might be more frequent. Always follow the manufacturer’s guidelines and consult with your veterinarian.

Flea pills work systemically. Once ingested, the active ingredients circulate in the dog’s bloodstream. When fleas bite the dog, they ingest the medication, which either kills or sterilizes them, disrupting their life cycle.

The safest treatment depends on the individual dog, its health, age, and lifestyle. Both oral and topical treatments have proven safe for many dogs. Always consult with your veterinarian to determine the best and safest option for your pet.

Yes, there is a flea injection known as “Program,” which acts as a flea birth control for dogs. It doesn’t kill adult fleas but prevents them from breeding. Discuss with your vet for more details and to see if it’s suitable for your pet.

Tick medicines work in various ways depending on the treatment type. Oral treatments typically circulate in the dog’s bloodstream, so when ticks bite, they ingest the medication and are either killed or repelled. Topical treatments can kill ticks on contact or when they bite.

Most flea and tick pills begin working within hours, often killing pests within 24 hours of administration.

Possible side effects can include vomiting, diarrhea, loss of appetite, or lethargy. However, many dogs experience no side effects at all. Always monitor your pet after administering a new treatment.

Consult your veterinarian before administering any medication to pregnant or nursing dogs.

Frequency varies by product. Some pills protect for a month, while others may last several months. Always follow label instructions and your veterinarian’s advice.

Not necessarily. Check the product details to see which species it targets, and choose one that covers pests prevalent in your area.

It’s crucial to consult your veterinarian before combining treatments to avoid potential drug interactions or overdosing.

Some pills offer protection against other parasites like heartworms or roundworms. Check the product description for full details.

Administer the pill as soon as you remember, and adjust the next dosage schedule accordingly. Always follow up with your veterinarian for specific guidance.

Most pills are safe for all breeds, but dosage may vary based on weight. Some breeds might have specific sensitivities, so consult your veterinarian.

Resistance can develop with any treatment. It’s good practice to rotate between different types of treatments yearly or as recommended by your veterinarian to minimize resistance risk.

Yes, there are natural treatments, such as essential oils (e.g., cedarwood, lavender, or lemon eucalyptus), diatomaceous earth, and herbal supplements. However, their effectiveness can vary. Always consult with a vet before using any alternative treatments.

No. Always use treatments specifically designed for dogs. Using cat treatments on dogs can be harmful and potentially fatal.

You can hide the pill in treats, use pill pockets, or mix it with their food. If they consistently refuse, consult your vet for alternative administration methods or treatments.

Some flea and tick medications might interact with other drugs. Always inform your veterinarian about any medications or supplements your dog is taking.


Navigating the myriad of flea and tick treatments can be daunting for any pet owner. However, with the right information and guidance, one can find the most suitable protection for their beloved canines. 

This review has highlighted various flea and tick pills, each with its unique strengths and considerations. From fast-acting solutions to all-natural approaches, there’s an option tailored to every dog’s needs. 

It’s essential to weigh the pros and cons, ensuring the chosen treatment aligns with your pet’s health requirements and lifestyle. Remember, a flea-free dog is not just about comfort; it’s about promoting overall well-being and health. 

With the insights provided in this article, you’re now equipped to make an informed decision, ensuring your furry friend remains happy, healthy, and itch-free.

Disclaimer: All the content on this site, including information and opinions expressed herein, as well as related notes, text, videos, and images, are meant for general informational purposes only. They are not intended to offer veterinary advice, and should not be used as a replacement for veterinary diagnosis, treatment, guidance, or services. DogPooch.com and its writers cannot be held liable or responsible for any costs, damages, or claims that may arise from the reader’s actions.