Dog Immune System Supplements

Email is reader-supported. If you buy through our links, we may earn a small commission at no extra cost to you. Read more here.

An immune system supplement for dogs is a product specifically formulated to support and strengthen the immune response of your four-legged friend. 

It comes in various forms – powders, chewable, and liquids – each containing a unique blend of essential vitamins, minerals, and other ingredients to boost canine immunity.

best supplements to boost dog’s immune system

Although dogs can naturally produce some immune-supporting substances, there are others they need to acquire from their diet. In some cases, regular dog food may not suffice, and that’s where immune system supplements come into play.

The benefits of these supplements are numerous. They can help your pet live a longer, healthier life, reduce the risk of various illnesses, and even speed up recovery when they’re under the weather. 

Some supplements are also beneficial for dogs with allergies, as they can help mitigate immune reactions.

So, join us as we delve into the world of immune system supplements for dogs. Our comprehensive reviews will guide you to make the best choice for your beloved canine companion, ensuring their tail keeps wagging healthily for years to come.

Table of Contents

Dog Immune System Supplements Reviews

Knowing the best option can be challenging with so many immune system supplement brands for dogs on the market. But not to worry, we have researched for you. 

After evaluating dozens of dog immune system vitamins, supplements, and treats, we have shortlisted the best dog immune system supplement options here for your consideration. We have analyzed based on features, key ingredients, customer reviews, and feedback. 

In this article, we will be reviewing the following dog immune system supplements, vitamins & treats.


Best Supplements For Dog’s Immune System

Zesty Paws Dog Immune System Supplements

Zesty Paws Allergy Immune Soft Chews + Hemp Seed are unique supplements that stand out for their exceptional blend of premium ingredients specifically designed to support your dog’s immune system function and tackle seasonal allergies.

A standout feature of these soft chews is their hemp enhancement. Hemp Seed, a rich source of Stearidonic acid (SDA), is known for bolstering immune function in dogs. 

Additionally, the supplements contain Qmin+, Curcumin, and BioPerine – a trio that works together to support liver function and facilitate absorption.

The inclusion of Wellmune, a clinically studied form of beta-glucan, adds an extra layer of immune support. 

The other premium ingredients like Taurine, Quercetin Dihydrate, Cod Liver Fish Oil, Vitamin C, and Ginger Root contribute to the all-around support of immune function and help maintain normal histamine levels.

These Cheese-Flavored, Hemp-Enhanced Soft Chews offer a new and exciting way for dogs to enjoy the health benefits of a comprehensive supplement.

Key Ingredients: Colostrum, Dried Fermentate, Apple Cider Vinegar, Salmon Oil, Astragalus Root, 5-Strain Gut Health Blend, Coconut Glycerin, Flaxseed, Garbanzo Flour, Lamb, Natural Flavor, Natural Vegetable Flavor, Palm Oil, Pea Flour, Powdered Cellulose, Rosemary Extract, Sunflower Lecithin.

👍 Pros
👎 Cons

BIXBI IMMUNITY is a unique powdered mushroom supplement designed to supercharge your pup’s immune system. 

Made with an exceptional blend of organic mushrooms, this supplement provides a wide range of antioxidants and polysaccharides, known to reduce the number of free radicals in your dog’s body.

The standout aspect of BIXBI IMMUNITY is its profound effect on your dog’s immune health. The mushrooms in the formula not only support normal inflammatory responses but also enhance the production of both white and red blood cells. 

This comprehensive support positions your pooch well to ward off an array of health challenges that may come their way.

Manufactured and sourced in the USA, this supplement guarantees high quality. The use of organic mushrooms further enhances its appeal, offering an all-natural way to boost your dog’s immune system. 

With BIXBI IMMUNITY, you can rest easy knowing that your dog is getting a potent blend of natural ingredients to maintain their overall health and wellness.

Key Ingredients: Organic Coriolus Versicolor, Organic Agaricus Blazei, Organic Reishi, Organic Shiitake, Organic Maitake, Organic Cordyceps, Organic King Trumpet, Organic Lion’s Mane.

👍 Pros
👎 Cons
Zesty Paws Dog Immune System Supplements Hemp Seed

Zesty Paws Allergy Immune Soft Chews + Hemp Seed supplement is an expertly formulated supplement that is packed with an array of premium ingredients, each contributing to your furry friend’s overall well-being.

The distinctive blend of hemp seed in these soft chews provides a source of Stearidonic acid (SDA), known to bolster immune function. 

Coupled with a potent mix of Curcumin, Qmin+, and BioPerine, these chews not only support healthy liver function but also ensure optimal absorption of the supplement’s powerful constituents.

One of the many highlights of this supplement is the inclusion of Wellmune, a clinically studied form of beta-glucan that is recognized for its immune-supporting properties. 

Additionally, a robust blend of Taurine, Quercetin Dihydrate, Cod Liver Fish Oil, Vitamin C, and Ginger Root work synergistically to maintain normal histamine levels and promote overall immune health.

These Zesty Paws Aller-Immune Bites come in a delicious cheese flavor that your dog will love. Formulated with your canine companion’s health in mind, this immune system supplement is an excellent choice for maintaining a zesty, healthy pup.

Key Ingredients: Organic Coriolus Versicolor, Organic Agaricus Blazei, Organic Reishi, Organic Shiitake, Organic Maitake, Organic Cordyceps, Organic King Trumpet, Organic Lion’s Mane.

👍 Pros
👎 Cons

PetHonesty’s Dog Immune System Supplements are designed to alleviate your furry friend’s seasonal allergies. This product promises to deliver a potent boost to their immune system while improving skin, environmental, and food allergies.

PetHonesty prioritizes gut health with the inclusion of probiotics in its supplements, aiming to fortify your dog’s immunity against potential diseases. 

These supplements also provide considerable support to your dog’s gastrointestinal tract, enabling their bodies to effectively combat issues such as leaky gut and diarrhea.

The all-natural, GMO-free composition of this supplement, devoid of chemicals and wheat, is an added boon, ensuring your pet’s intake is free of any potentially harmful substances. 

Moreover, it also assists in maintaining normal histamine levels and soothing skin-related issues that arise due to seasonal allergies.

The power-packed blend of natural ingredients and probiotics promotes not only healthy digestion but also a normal immune response, allowing your dog to thrive in optimal health.

Key Ingredients: Carrot, Coconut Glycerin, Flaxseed, Mixed Tocopherols, Natural Flavor (from Oregano, Plums, Flaxseed), Oat Flour, Palm Fruit Oil, Powdered Cellulose, Rosemary Extract, Salmon, Sunflower Lecithin, Sweet Potato.

👍 Pros
👎 Cons
Zesty Paws Senior Dog Immune System Supplements

Catering to the special needs of your aging canine companion, Zesty Paws presents the Allergy Immune Supplement for Senior Dogs. 

This premium supplement is a cornucopia of all the essential nutrients required to support the immune defenses and gut health of your elderly pet.

The core of the Advanced Aller-Immune Bites is EpiCor, a nutrient-packed ingredient that supplies your dog with an array of vitamins, protein, fiber, polyphenols, and antioxidants, all of which are clinically proven to fortify their natural immune defenses.

The supplement’s holistic blend of Colostrum, Quercetin, Vitamin C, Apple Cider Vinegar, Yucca, and Organic Licorice Root delivers multiple benefits, including alleviating allergies, boosting immune function, and supporting digestion. 

The inclusion of Wild Alaskan Salmon Oil in each chew provides Omega 3 fatty acids EPA & DHA that offer skin support for dogs and help combat allergies causing itchy skin and hot spots.

Furthermore, the proprietary Prebiotic and Probiotic blend featuring five strains of Probiotics and PreforPro, a premium clinically-proven Prebiotic, works harmoniously to sustain healthy gut bacteria and foster the growth of Probiotic species.

Key Ingredients: Alltech Nvgen Pack, Colostrum, Wild Alaskan Salmon Oil, Epicor Fermentate,  5-Strain Probiotic Blend, Bromelain, Flaxseed, Garbanzo Flour, Mixed Tocopherols, Palm Fruit Oil, Pea Flour, Powdered Cellulose, Rosemary Extract, Salmon, Sorbic Acid, Sunflower Lecithin.

👍 Pros
👎 Cons

ZENAPET Immune Support For Dogs

Zenapet Dog Immune System Supplements

Zenapet Dog Immune Support is a superfood supplement that is crafted to fortify your pet’s defenses against pathogens and toxins, with its rich, all-natural, and gluten-free formulation that also doubles as a delicious treat when mixed into their food.

Zenapet’s unique blend brings together vitamins B-1, B-2, B-6, A, C, D, and E, supporting not only your dog’s immune function but also their overall wellness. 

It leverages the power of four plant-based nutritional components – turkey tail mushroom powder, beta-glucan, spirulina, and resveratrol – to forge a potent formula proven to enhance health.

Turkey tail mushroom works wonders on the immune system while facilitating digestion and urinary health. Beta-glucan, a powerful immune booster, assists in combatting inflammation and infections while potentially calming hyperactive dogs. 

A fan favorite, nutritional yeast is teeming with beneficial B vitamins and complete proteins, including nine amino acids. 

Spirulina, the final active ingredient, works proficiently to cleanse the body of toxins, enhance gastrointestinal health, and improve overall skin and coat health.

This GMO-free, preservative-free, and artificial flavor-free supplement is made in the USA and presents a comprehensive, natural approach to supporting your pet’s immune system and health.

Key Ingredients: Proprietary Blend of Turkey Tail Mushroom, Beta-Glucan, Spirulina, Trans-Resveratrol, Plant Based Cellulose, Nutritional Yeast.

👍 Pros
👎 Cons
Raw Paws Organic Sea Kelp Supplement For Dog Immune System and Skin Coat

Raw Paws Organic Sea Kelp Supplement is a mineral-rich, organic treasure harvested from the pristine waters off the coast of Iceland. This supplement is more than just a product; it’s a conduit for a more vibrant and healthier life for your canine companion.

As the #1 source of natural trace minerals, this sea kelp supplement is a powerhouse, enhancing your dog’s immune system, promoting healthy skin and coat, reducing itching, and fortifying their blood. 

The blend is infused with a comprehensive array of 60 different vitamins, minerals, and trace elements, as well as 21 amino acids. Its excellent fiber content promotes your pup’s digestion and contributes to overall wellness.

Administering the supplement is a breeze. Simply sprinkle it over your pup’s food for an enriching nutritional boost. Your pet will relish the rich, fresh taste of the organic sea kelp flavor. 

The supplement is organic, GMO-free, grain-free, and free from any preservatives, ensuring its all-natural goodness for your furry friend.

An excellent source of iodine, this organic sea kelp supplement aids in the proper functioning of glands such as the thyroid, in turn, bolstering metabolism. 

Enhanced metabolism brings about increased energy levels, reduced inflammation, and a more robust defense against infections. Suitable for dogs and cats of all breeds and ages, the supplement is available in an 8 oz resealable bag for your convenience.

Key Ingredients: Certified USDA Organic Icelandic Sea Kelp

👍 Pros
👎 Cons

Best Immune Support Dog Treats

CBD Dog Treats with Sweet Potato For Heart and Immune System

The HolistaPet +HEART & IMMUNE CARE CBD Dog Treats are a paw-fiction in disguise for your fur friend. Specially formulated with an exciting blend of Sweet Potatoes, Flax seeds, and Blueberries, these treats are not just a fun snack but a powerhouse of health benefits.

Each bite of the blueberry and sweet potato flavored treats is a step towards strengthening your pet’s cardiovascular system and promoting a healthier coat and skin. 

What sets this product apart is the inclusion of superfoods like Hemp Seed Powder and Full Spectrum CBD Oil. Hemp Seed Powder, rich in omega fatty acids and protein, nourishes your pup from the inside, while Full Spectrum CBD Oil contributes to overall wellness.

These treats are particularly beneficial for dogs with weakened immune systems, digestive issues, or skin problems that cause constant itching. Besides, who would resist the appetizing blend of sweet potato and blueberry flavor?

The company’s commitment to quality shines through its use of 100% natural ingredients, ensuring zero GMOs, gluten, or dairy in the mix. This makes the HolistaPet +HEART & IMMUNE CARE CBD Dog Treats an exceptional choice for pet parents who want the best for their beloved companions.

Key Ingredients: Blueberries, Flaxseed, Hemp Seed Powder, CBD Oil (Cannabidiol), Sweet Potatoes, Rolled Oats, Brown Rice Flour, Molasses, Cinnamon, Coconut Oil

👍 Pros
👎 Cons

PupJoy Skin & Immune Support Pup Packets

PupJoy Omega 3 Dog Supplement For Skin Coat

PupJoy Skin & Immune Support Pup Packets by Coromega are a game-changer in the world of canine wellness. 

Not only will your dog enjoy the delightful pudding-like texture, but you will also appreciate the myriad health benefits that these supplements bring to your furry friend.

Each Pup Packet offers an exquisite blend of Omega-3 and Vitamin E, designed to support your dog’s skin health and strengthen their immunity. 

The 650mg Omega-3 fatty acids, 350mg EPA, and 230mg DHA within each packet are just the right elements your dog needs for an immune boost.

One of the standout features of these supplements is their formulation with wild-caught South American fish, ensuring that your pup is getting high-quality, natural sources of Omega-3. Plus, with no preservatives or additives, you can have peace of mind about what you’re feeding your furry friend.

Whether you mix it into their food or give it as a treat, these all-natural fish-flavored packets will be an instant hit with your pup. 

Reward your four-legged family member with the dual benefits of taste and health, wrapped in one simple packet – the Coromega Pup Packet!

Key Ingredients: Omega-3 Fatty Acids, ascorbic acid, citric acid, egg yolk, (pasteurized), mixed tocopherols, potassium sorbate, sodium ascorbate, sodium benzoate, water, xanthan gum

👍 Pros
👎 Cons

How To Boost Your Dog's Immune System?

Boosting your dog’s immune system is not a complex task. Other than supplements here are some ways you can help your canine companion stay in optimal health:

Healthy Diet

Like humans, dogs need a balanced diet to maintain a healthy immune system. Their diet should include a good balance of proteins, carbohydrates, and fats, along with essential vitamins and minerals. 

A diet rich in fruits, vegetables, lean meats, and whole grains can provide these necessary nutrients.

Regular Exercise

Exercise isn’t just important for your dog’s physical health; it’s also essential for their immune health. 

Regular physical activity can boost your dog’s immune system by increasing the circulation of antibodies and white blood cells that fight off diseases. Aim for daily walks, playtimes, or any other form of exercise your dog enjoys.


As we’ve mentioned in our article, immune system supplements can play a key role in supporting your dog’s overall health. Ingredients like antioxidants, probiotics, Omega-3 fatty acids, and essential vitamins and minerals can help boost your dog’s immunity.

Regular Vet Checkups

Regular veterinary checkups are essential for preventive care. Routine vaccinations and deworming help protect your dog from various diseases. Your vet can also detect any potential health problems early, which can make treatment more effective.


Keeping your dog well-hydrated is another simple yet effective way to support their immune health. Water aids in the digestion and absorption of nutrients, as well as the elimination of waste and toxins from the body.

Maintain a Healthy Weight

Obesity can lead to numerous health issues in dogs, including a weakened immune system. Regular exercise and portion control can help maintain a healthy weight and prevent obesity.

Minimize Stress

Long-term stress can compromise your dog’s immune system. Try to provide a stable, loving environment, and avoid major changes in your dog’s routine if possible. Mental stimulation through games, puzzles, and training can also help keep stress at bay.

What Are The Benefits of Immune System Supplements for Dogs?

Immune system supplements for dogs are designed to help bolster their overall health, especially their ability to fight off infections and diseases. 

They are formulated with a variety of essential vitamins, minerals, and other health-boosting compounds, each offering unique benefits. Here are some of the advantages your dog can reap from these supplements:

Enhanced Immunity

As the name suggests, the primary benefit of these supplements is to strengthen your dog’s immune system, enhancing its body’s natural defenses. 

A stronger immune system can help protect your pet from a range of illnesses, from minor infections to more serious diseases.

Improved Digestive Health

Many immune system supplements for dogs include probiotics and prebiotics, which are beneficial for gut health. A healthier gut not only improves digestion but also supports immune function, as a significant portion of the immune system is housed in the gastrointestinal tract.

Reduced Allergies and Inflammation

Certain immune-boosting supplements contain anti-inflammatory ingredients such as omega-3 fatty acids. These can help alleviate symptoms of allergies, reduce inflammation, and aid in skin and coat health.

Antioxidant Support

Antioxidants are crucial for preventing cellular damage caused by free radicals. Many immune supplements contain antioxidants such as vitamins A, C, and E, and selenium, which can help protect your dog’s cells and contribute to longevity.


Some immune system supplements can assist in detoxifying the body by promoting the elimination of waste products and toxins, which can otherwise compromise your dog’s immune response.

Enhanced Energy Levels and Overall Well-being

With a bolstered immune system, improved gut health, and a body free of harmful toxins, your dog may enjoy increased energy levels and an overall sense of well-being.

Aid in Recovery

If your dog is recuperating from an illness or surgery, immune system supplements can aid in their recovery by providing the extra nutritional support their body needs during this time.

Supports Healthy Aging

As dogs age, their immune function naturally declines. Certain immune system supplements can help counteract this, supporting healthy aging and helping older dogs maintain an active, healthy lifestyle.

Improved Skin and Coat Health

Some immune system supplements, especially those containing omega fatty acids and certain vitamins, can contribute to a healthier, shinier coat and healthier skin, reducing issues like dryness, flaking, and itching.

Reduction of Stress and Anxiety

Certain nutrients, like the B vitamins found in some immune system supplements, can help regulate the body’s response to stress and promote a sense of calm, which can be particularly beneficial for dogs prone to anxiety.

Joint Health

Certain immune system supplements contain ingredients that support joint health, such as glucosamine, chondroitin, and omega-3 fatty acids. These can be particularly beneficial for older dogs or breeds prone to joint issues.

Improved Metabolic Function

By providing a broad range of essential nutrients, immune system supplements can help support your dog’s metabolic function, promoting healthy weight, energy levels, and overall vitality.

Promotion of Heart Health

Some supplements, particularly those containing omega fatty acids and antioxidants, can support heart health, promoting optimal cardiovascular function.

Prevention of Nutrient Deficiencies

Even a well-balanced diet may not provide all the nutrients in the amounts your dog needs. Immune system supplements can help fill in any nutritional gaps, preventing deficiencies that could impair immune function.

Factors To Consider When Buying Immune System Supplements for Dogs

Choosing the right immune system supplement for your dog involves considering several key factors. Here’s what you should keep in mind:


One of the most important aspects to look at is the ingredients used in the supplement. Look for natural, high-quality ingredients and avoid products with artificial colors, flavors, or unnecessary fillers. 

The supplement should contain beneficial elements like vitamins, minerals, antioxidants, probiotics, and omega-3 fatty acids.

Age, Size, and Breed of Your Dog

Different dogs have different nutritional needs depending on their age, size, and breed. Puppies, adult dogs, and senior dogs each require different types and amounts of nutrients. 

Similarly, a small breed dog will have different nutritional requirements than a large breed dog. Choose a supplement that’s appropriate for your dog’s specific needs.

Health Status

If your dog has a specific health concern or is currently undergoing treatment for an illness, you’ll want to choose a supplement that addresses their particular needs. Always consult your vet before starting any new supplement, especially if your pet has health issues.

Product Quality and Manufacturer Reputation

Look for products from reputable manufacturers that maintain high-quality standards. Check if the product is manufactured in a facility that follows Good Manufacturing Practices (GMPs).

Reading customer reviews and seeking professional recommendations can also help you gauge product quality.


Supplements with certifications from independent testing organizations, like the National Animal Supplement Council (NASC), can provide added assurance of quality and safety.

Ease of Administration

Some dogs can be picky eaters or may have difficulty swallowing pills. Consider the format of the supplement—whether it’s a chew, liquid, or powder—and choose one that you think your dog will accept easily.

Value for Money

Consider the cost per serving of the supplement and balance this with the quality and effectiveness of the product. A cheaper supplement may not provide as many benefits, while the most expensive option isn’t necessarily the best.

Veterinary Approval

Always consult your vet before adding a new supplement to your dog’s regimen. They can provide guidance based on their knowledge of your dog’s health and nutritional needs.

Frequently Asked Questions (FAQs)

Generally, yes, immune system supplements made from natural ingredients and produced by reputable manufacturers are safe for dogs. However, it’s always recommended to consult with your vet before introducing any new supplement into your pet’s diet.

This can vary depending on the specific supplement and your dog’s individual health status. However, generally, you might start seeing improvements in your dog’s overall health and vitality within a few weeks of consistent use.

You should always consult with your vet before combining supplements with medication. Some supplements can interact with medications, potentially affecting their effectiveness or causing side effects.

Yes, immune system supplements can be used as a preventive measure to help maintain your dog’s overall health. They can fill nutritional gaps and strengthen your dog’s natural defenses, even if they’re already healthy.

It depends on their diet and health status. Some puppies may benefit from certain supplements, while others may not need them. Always consult your vet before giving supplements to puppies.

While immune system supplements can support overall health and help prevent illness, they are not a cure for existing diseases. If your dog is unwell, it’s essential to seek veterinary care.

Most supplements should be stored in a cool, dry place out of direct sunlight. Always check the label for specific storage instructions.

No, supplements should not replace a balanced diet but rather complement it. They are designed to provide additional nutrients that your dog may not be getting from their regular diet.

No, it’s not recommended to give your dog supplements intended for humans. Dogs have different nutritional needs and may react differently to certain ingredients. Always use supplements specifically formulated for dogs.

The frequency of administration depends on the specific supplement and the recommendations of your vet. Always follow the dosage instructions provided on the product packaging.

Generally, natural immune system supplements are safe and have minimal side effects. However, individual dogs may react differently. If you notice any adverse reactions, such as digestive upset, changes in behavior, or allergic reactions, discontinue use and consult your vet.

Yes, immune system supplements can be particularly beneficial for older dogs whose immune systems have naturally declined with age. They can help support overall health and vitality in senior dogs.

Many supplements come in different forms like chews, liquids, or powders that can be mixed into food. If your dog is a picky eater, consider a form they might find more palatable.

No, they can vary significantly in terms of ingredients, quality, and effectiveness. That’s why it’s crucial to consider factors such as the product’s ingredients, the manufacturer’s reputation, and the specific needs of your dog when choosing a supplement.

Many immune system supplements contain ingredients, such as omega-3 fatty acids and vitamins, that can help support healthy skin and a shiny coat.

Certain supplements can help manage allergies by boosting the immune system and reducing inflammation. However, they should not replace any medications prescribed by your vet for allergy control.


Wrapping up, choosing the right immune system supplement for your dog can significantly contribute to their overall health and vitality. 

A high-quality supplement, tailored to your dog’s specific needs, can enhance their immune function, provide necessary nutrients, and protect against various health concerns. 

However, remember that while these supplements offer numerous benefits, they are not a replacement for a balanced diet, regular exercise, and routine veterinary care. 

Always consult with your vet before adding any new supplement to your dog’s diet. With the right care and attention, your canine companion can enjoy a healthier, happier, and longer life.

Disclaimer: All the content on this site, including information and opinions expressed herein, as well as related notes, text, videos, and images, are meant for general informational purposes only. They are not intended to offer veterinary advice, and should not be used as a replacement for veterinary diagnosis, treatment, guidance, or services. and its writers cannot be held liable or responsible for any costs, damages, or claims that may arise from the reader’s actions.